When evaluating gaming cases, prioritize form factor compatibility (ATX, Micro-ATX, or ITX) to ensure the motherboard fits. Crucial technical specs include GPU clearance (length in mm) to accommodate modern triple-fan cards and CPU cooler height limits. For high-end builds, ensure the case supports liquid cooling radiators (240mm, 280mm, or 360mm) at the top or front panels. Additionally, look for cable management space (at least 20-25mm behind the tray) and tool-less entry designs to enhance the end-user experience.